Scope of IEEE Transactions on Computational Biology and Bioinformatics

IEEE Transactions on Computational Biology and Bioinformatics emphasizes the algorithmic, mathematical, statistical and computational methods that are central in bioinformatics and computational biology; the development and testing of effective computer programs in bioinformatics; the development of biological databases; and important biological results that are obtained from the use of these methods, programs and databases; the emerging field of Systems Biology, where many forms of data are used to create a computer-based model of a complex biological system.

The publication represents a mixture of three research modalities: a) fundamental methodological, algorithmic, mathematical and statistical research directly motivated by biological issues; b) papers focusing on experimental and implementation issues; and c) papers on serious application of methods and programs that lead to discoveries of biological significance. Increasingly, papers contain elements of all three modalities. Specific topics of interest include, but are not limited to, sequence analysis, comparison and alignment methods; motif, gene and signal recognition; molecular evolution; phylogenetics and phylogenomics; determination or prediction of the structure of RNA and Protein in two and three dimensions; DNA twisting and folding; gene expression and gene regulatory networks; deduction of metabolic pathways; micro-array design and analysis; proteomics; functional genomics; molecular docking and drug design; computational problems in genetics such as linkage and QTL analysis, linkage disequilibrium analysis in populations, and haplotype determination; systems biology.

Cosponsors

Technical cosponsors are the IEEE Control Systems Society and the IEEE Engineering in Medicine and Biology Society.

Additional Information

TCBB is a bimonthly journal that publishes archival research results related to the algorithmic, mathematical, statistical, and computational methods that are central in bioinformatics and computational biology.

While the orientation of the transactions is on computational issues, at the same time, the journal must insist that the papers have a genuine connection to biology and not just concern computational problems that are “motivated” by biology. As the field matures, it is expected that a large percentage of the papers in the journal will validate new methods and ideas with real or realistically simulated data. It will be common for papers to be the product of joint research by computationally oriented researchers together with biologists.

TCBB offers authors access to Code Ocean. Code Ocean is a cloud-based executable research platform that allows authors to share their algorithms in an effort to make the world’s scientific code more open and reproducible. 

Special Issue on AI-Driven Advancements in Bioinformatics for Life Science
Día de Entrega: 2026-02-28

This IEEE Transactions on Computational Biology and Bioinformatics Special Issue aims to publish original manuscripts focusing on novelties and applications on AI based technologies for boosting Bioinformatics application. Publication is scheduled for Summer 2026.

Candidates for this issue are also papers that received high review scores in ACM BCB 2025 reviewing process and/or that the presentation at the ACM BCB 2025 conference received positive feedback and that generated discussion on the main topic of this SI.

This issue also aims to reserve room for new submissions that may fit with the SI main topic. The SI aims to contain up to a total of 8 papers.

In case of ACM BCB conference papers, manuscripts should contain at least 70 % of original contents.

Review processes will be managed following the TCBB standard review process. For papers presented at ACM BCB 2025, the extended version will be reviewed by at least one BCB 2025 Technical Program Chairs to guarantee a rigorous process of manuscript improvement.