The IEEE Transactions on Multi-Scale Computing Systems (TMSCS) is a peer-reviewed publication devoted to computing systems that exploit multi-scale and multi-functionality. These systems consist of computational modules that utilize diverse implementation scales (from micro down to the nano scale) and heterogeneous hardware and software functionalities;  moreover, these modules can be based on operating principles and models that are valid within but not necessarily across their respective scales and computational domains. Contributions to TMSCS must address computation of information and data at higher system-levels for processing by digital and emerging domains. These computing systems can also rely on diverse frameworks based on paradigms at molecular, quantum and other physical, chemical and biological levels. Innovative techniques such as inexact computing, management/optimization of smart infrastructures and neuromorphic modules are also considered within scope.

This publication covers pure research and applications within novel topics related to high performance computing, computational sustainability, storage organization and efficient algorithmic information distribution/processing;  articles  dealing  with  hardware/software  implementations  (functional  units,  architectures and algorithms), multi-scale modeling and simulation, mathematical models and designs across  multiple  scaling  domains  and  functions  are  encouraged.  Novel  solutions  based  on  digital  and  non-traditional  emerging  paradigms  are  sought  for  improving  performance  and  efficiency  in  computation. Contributions on related topics would also be considered for publication.